Wetenschappelijke publicaties

Category "Genetic other"

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles Hautakangas 2022
Associations of carotid intima media thickness with gene expression in whole blood and genetically predicted gene expression across 48 tissues Castaneda AB 2021
Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure. Wang 2021
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability Lagou 2021
Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline Gorski, 2021
Gene-educatinos attainment interactions in a multi-acenstry genome-wide meta-analysis identify novel blood pressure loci de las Fuentas 2021
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders Blokland 2022
Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci Ahluwalia, TS 2021
Genome-wide association study identifies 48 common genetic variants associated with handedness Cuellar-Partida G 2021
Genome-wide association study identifies 48 common genetic variants associated with handedness Cuellar-Partida 2020
Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. Sønderby IE 2020
Genome-wide association analysis in humans links nucleotide metabolism to leukocyte telomere length. Li C 2020
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. Tin A 2019
Genetic architecture of subcortical brain structures in 38,851 individuals. Satizabal CL 2019
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration. Noordam R 2019
A catalog of genetic loci associated with kidney function from analyses of a million individuals. Wuttke M 2019
Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. Sonderby IE 2019
Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances. Timmers PR 2019
Genome-Wide Association scan of serum urea in European populations identifies two novel loci. Thio 2019
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders Ligthart S 2018
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Franceschini N 2018
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Kilpeläinen TO 2019
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits Evangelou E 2018
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. Feitosa MF 2018
Heritability and GWAS studies for monocyte-lymphocyte ratio Lin BD 2017
2SNP heritability and effects of genetic variants for neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio. Lin BD 2017
The low single nucleotide polymorphism heritability of plasma and saliva cortisol levels. Neumann A 2017
Novel blood pressure locus and gene discovery using genome-wide association study and expression data sets from blood and the kidney. Wain LV 2017
Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling. Ferreira MA 2017
Genetic loci associated with heart rate variability and their effects on cardiac disease risk. Nolte IM 2017
Genome-wide physical activity interactions in adiposity – A meta-analysis of 200,452 adults. Graff M 2017
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape Ried JS 2016
Correcting for cell-type effects in DNA methylation studies: reference-based method outperforms latent variable approaches in empirical studies. Hattab MW 2017
Genetic variants associated with circulating parathyroid hormone Robinson-Cohen C 2017
Novel genetic loci underlying human intracranial volume identified through genome-wide association Adams HH 2016
Genome-wide analysis identifies 12 loci influencing human reproductive behavior Barban N 2016
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals Ehret GB 2016
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine Gormley P 2016
Identification of common genetic variants influencing spontaneous dizygotic twinning and female fertility Mbarek H 2016
Consistency of biological networks inferred from microarray and sequencing data Vinciotti V 2016
Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels van Leeuwen EM 2016
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function Pattaro C 2016
Integrative approaches for large-scale transcriptome-wide association studies Gusev A 2016
Disease and Polygenic Architecture: Avoid trio design and appropriately account for unscreened control subjects for common disease. Peyrot WJ 2016
Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study. Vimaleswaran KS 2015
Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons. Pilling JC 2016
The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study. Winkler TW 2015
An in silico post-GWAS analysis of C-reactive protein loci suggests an important role for interferons. Nucleic Acids Research. Vaez A 2015
Discovery and fine-mapping of glycaemic and obesity-related trait loci using high-density imputation. Horikoshi M 2015
Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels. Draisma HH 2015
DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and non-coding transcripts Zhernakova DV 2013
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Rietveld C 2013
A new regulatory variant in the interleukin-6 receptor gene associates with asthma risk. Revez JA 2013
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. Randall JC 2013
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations Kottgen A 2013
Loci influencing blood pressure identified using a cardiovascular gene-centric array. Ganesh SK 2013
The role of adiposity in cardiometabolic traits: a mendelian randomization analysis. Fall T 2013
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture Berndt SI 2013
Genome-wide meta-analysis identifies new susceptibility loci for migraine. Anttila V 2013
Population structure, migration, and diversifying selection in the Netherlands. Abdellaoui A 2013
FTO genotype is associated with phenotypic variability of body mass index Yang J 2012
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Scott RA 2012
A genome-wide association search for type 2 diabetes genes in African Americans. Palmer ND 2012
Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies Murabito JM 2012
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Manning A 2012
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. Dastani Z 2012
Genome-wide meta-analysis of common variant differences between men and women. Boraska V 2012
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Wain LV 2011
LPAR1 and ITGA4 regulate peripheral blood monocyte counts. Maugeri N 2011
Genetic architecture of circulating lipid levels. Demirkan A 2011
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Chambers JC 2011
Meta-analysis of Genome-Wide Association studies in > 80 000 subjects identifies multiple loci for C-reactive protein levels. Dehghan A 2011
Biological, clinical and population relevance of 95 loci for blood lipids. Teslovich TM 2010
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Speliotes EK 2010
Genome-Wide Association Study of blood pressure extremes identifies variant near UMOD associated with hypertension. Padmanabhan S 2010
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Lango Allen H 2010
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Heid IM 2010
Genome-wide association analysis identifies multiple loci related to resting heart rate. Eijgelsheim M 2010
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk Dupuis 2010
Genetic loci influencing kidney function and chronic kidney disease Chambers JC 2010
Global similarity with local differences in linkage disequilibrium between the Dutch and HapMap-CEU populations Pardo L 2009
Sequence variants in three loci influence monocyte counts and erythrocyte volume Ferreira MAR 2009
A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation. Estrada K 2009
Common variants in TMPRSS6 are associated with iron status and erythrocyte volume Benyamin B 2009
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts Aulchenko YS 2009
Heritability and genomics of gene expression in peripheral blood. Wright FA 2014
The contribution of the functional IL6R polymorphism rs2228145, eQTLs and other genome-wide SNPs to the heritability of plasma sIL-6R levels. van Dongen J 2014
Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging van den Akker EB 2014
Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. Tragante V 2014
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP consortia. Simino J 2014
Identifying genetic variants for heart rate variability in the acetylcholine pathway. Riese H 2014
Sex differences in the human peripheral blood transcriptome Jansen R 2014
Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and Type 2 diabetes susceptibility. Guigas B 2014
Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty Cousminer DL 2014
Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels van Leeuwen EM 2015
The impact of low-frequency and rare variants on lipid levels. Surakka I 2015
New genetic loci link adipose and insulin biology to body fat distribution. Shungin D 2015
Modulation of genetic associations with serum urate levels by body-mass-index in humans. Huffman JE 2015
Common genetic variants influence human subcortical brain structures. Hibar DP 2015
Genome-wide association study of kidney function decline in individuals of European descent Gorski M 2015
Age- and sex-specific causal effects of adiposity on cardiovascular risk factors. Fall T 2015
Educational attainment influences levels of homozygosity through migration and assortative mating Abdellaoui A 2015
Seventy-five genetic loci influencing the human red blood cell van der Harst P 2012
Meta-analysis of genome-wide association for migraine in six population-based European cohorts Ligthart L 2011
The functional -2G variant of the mineralocorticoid receptor modulates basal and salt-dependent rennin and aldosterone levels and associates with higher blood pressure van Leeuwen N 2010